Sunday, April 7, 2013

Despite threats, risks temper Korea war tensions

FILE - In this Feb. 7, 2013 file photo, an unidentified U.S. Marine from 3-Marine Expeditionary Force 1st Battalion from Kaneho Bay, Hawaii, aims his gun during a joint military winter exercise with their South Korean counterparts in Pyeongchang, east of Seoul, South Korea. As tensions rise on the Korean Peninsula, one thing remains certain: All sides have good reason to avoid an all-out war. The last one, six decades ago, killed an estimated 4 million people. (AP Photo/Lee Jin-man, File)

FILE - In this Feb. 7, 2013 file photo, an unidentified U.S. Marine from 3-Marine Expeditionary Force 1st Battalion from Kaneho Bay, Hawaii, aims his gun during a joint military winter exercise with their South Korean counterparts in Pyeongchang, east of Seoul, South Korea. As tensions rise on the Korean Peninsula, one thing remains certain: All sides have good reason to avoid an all-out war. The last one, six decades ago, killed an estimated 4 million people. (AP Photo/Lee Jin-man, File)

A North Korean man walks past propaganda posters in Pyongyang, North Korea, on Tuesday, March 26, 2013, that threaten punishment to the "U.S. imperialists and their allies." The U.S. recently tightened sanctions against North Korea after Pyongyang tested a nuclear device in February in defiance of international bans against atomic activity. (AP Photo/Kim Kwang Hyon)

FILE - In this April 4, 2013 file photo, soldiers of the U.S. Army 23rd chemical battalion carry a U.S. and South Korean flag during a ceremony to recognize the battalion's official return to the 2nd Infantry Division based in South Korea at Camp Stanley in Uijeongbu, north of Seoul. As tensions rise on the Korean Peninsula, one thing remains certain: All sides have good reason to avoid an all-out war. The last one, six decades ago, killed an estimated 4 million people. (AP Photo/Lee Jin-man, File)

FILE - In this April 5, 2013 file photo, South Korean army reservists salute while denouncing North Korea for their escalating threat of war, during their Foundation Day ceremony at a gymnasium in Seoul, South Korea. As tensions rise on the Korean Peninsula, one thing remains certain: All sides have good reason to avoid an all-out war. The last one, six decades ago, killed an estimated 4 million people. (AP Photo/Ahn Young-joon, File)

(AP) ? As tensions rise on the Korean Peninsula, one thing remains certain: All sides have good reason to avoid an all-out war. The last one, six decades ago, killed an estimated 4 million people.

North Korea's leaders know that war would be suicidal. In the long run, they cannot expect to defeat the United States and successfully overrun South Korea. War would be horrific for the other side as well. South Korea could suffer staggering casualties. The U.S. would face a destabilized major ally, possible but unlikely nuclear or chemical weapons attacks on its forward-positioned bases, and dramatically increased tensions with North Korea's neighbor and Korean War ally, China.

Here's a look at the precarious balance of power that has kept the Korean Peninsula so close to conflict since the three-year war ended in 1953, and some of the strategic calculus behind why, despite the shrill rhetoric and seemingly reckless saber-rattling, leaders on both sides of the Demilitarized Zone have carefully avoided going back over the brink.

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THE SEA OF FIRE

Even without nuclear weapons, North Korea has an ace in the hole. Most experts believe its claims to have enough conventional firepower from its artillery units to devastate the greater Seoul area, South Korea's bustling capital of 24 million. Such an attack would cause severe casualties ? often estimated in the hundreds of thousands ? in a very short period of time.

Many of these artillery batteries are already in place, dug in and very effectively camouflaged, which means that U.S. and South Korean forces cannot count on being able to take them out before they strike. Experts believe about 60 percent of North Korea's military assets are positioned relatively close to the Demilitarized Zone separating the countries.

North Korea's most threatening weapons are its 170 mm Koksan artillery guns, which are 14 meters long and can shoot conventional mortar ammunition 40 kilometers (25 miles). That's not quite enough to reach Seoul, which is 50 kilometers (30 miles) from the DMZ. But if they use rocket-assisted projectiles, the range increases to about 60 kilometers (37 miles). Chemical weapons fired from these guns could cause even greater mayhem.

North Korea experts Victor Cha and David Kang posted on the website of Foreign Policy magazine late last month that the North can fire 500,000 rounds of artillery on Seoul in the first hour of a conflict.

Even so, not everyone believes North Korea could make good on its "sea of fire" threats. Security expert Roger Cavazos, a former U.S. Army officer, wrote in a report for the Nautilus Institute last year that, among other things, North Korea's big guns have a high rate of firing duds, pose more of a threat to Seoul's less populated outer suburbs, and would be vulnerable to counterattack as soon as they start firing and reveal their location.

"North Korea occasionally threatens to "turn Seoul into a Sea of Fire," he wrote. "But can North Korea really do this? ... The short answer is they can't; but they can kill many tens of thousands of people, start a larger war and cause a tremendous amount of damage before ultimately losing their regime."

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FIRST STRIKES, PRE-EMPTIVE STRIKES

This is what both sides say concerns them the most.

North Korea says it is developing nuclear weapons and long-range missiles as a deterrent to keep the United States or South Korea from attacking it first. The reasoning is that Washington will not launch a pre-emptive strike if North Korea has a good chance of getting off an immediate ? and devastating ? response of its own.

Along with its artillery aimed at Seoul and other targets in South Korea, North Korea is developing the capacity to deploy missiles that are mobile, thus easier to move or hide. North Korea already has Rodong missiles that have ? on paper at least ? a range of about 1,300 kilometers (800 miles), enough to reach several U.S. military bases in Japan. Along with 28,000 troops in South Korea, the U.S. has 50,000 troops based in Japan.

North Korea is not believed to be capable of making a nuclear weapon small enough to fit on a long-range missile capable of hitting the United States. But physicist David Albright, president of the Institute for Science and International Security, believes it may be capable of mounting nuclear warheads on Rodongs. In any case, Pyongyang is continuing to pursue advancements, apparently out of the belief that it needs nuclear-tipped missiles capable of reaching the U.S. to have a credible deterrent.

The United States rejects the North's claim that such a deterrent is necessary, saying it does not intend to launch pre-emptive strikes against North Korea. At the same time, Washington has made it clear that it could.

During ongoing Foal Eagle military maneuvers in South Korea, two U.S. B-2 strategic stealth bombers, flying from their base in Missouri, conducted a mock bombing run on a South Korean range. The B-2 is capable of carrying nuclear weapons, precision bombs that could take out specific targets such as North Korean government buildings, and massive conventional bombs designed to penetrate deep into the ground to destroy North Korean tunnels and dug-in military positions. One big problem, however, is determining where the targets are.

Amid heightened tensions over North Korea's nuclear weapons program in 1994, President Bill Clinton reportedly considered a pre-emptive strike, but decided the risks were too high.

___

CHINA'S DILEMMA

Without China, North Korea wouldn't exist. The Chinese fought alongside the North Koreans in the Korean War and have propped up Pyongyang with economic aid ever since.

Beijing has grown frustrated with Pyongyang, especially over its nuclear program. China and the U.S. worked together in drafting a U.N. resolution punishing the North for its Feb. 12 nuclear test.

But China still has valid reasons not to want the regime to suddenly collapse.

War in Korea would likely spark a massive exodus of North Korean civilians along its porous 1,300-kilometer (800-mile) border, which in turn could lead to a humanitarian crisis or unrest that the Chinese government would have to deal with. The fall of North Korea could pave the way for the United States to establish military bases closer to Chinese territory, or the creation of a unified Korea over which Beijing might have less influence.

China, the world's second-largest economy, also has significant trade with South Korea and the United States. Turmoil on the Korean Peninsula would harm the economies of all three countries.

Patrick Cronin, an Asia expert at the Center for a New American Security and a senior State Department official during the George W. Bush administration, said Beijing is helping set up back-channel negotiations with North Korea to ease the tensions. But he warned that the U.S. isn't likely to win China over as a reliable partner against North Korea beyond the current flare-up.

"There are limits to how far China and the U.S. have coincidental interests with regard to North Korea," he said.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/cae69a7523db45408eeb2b3a98c0c9c5/Article_2013-04-07-AS-NKorea-The-War-Calculus/id-820dd95e12884c5ea02ebdcbce3caebb

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Saturday, April 6, 2013

Memphis protests: How rookie photographer captured history

Vernon Matthews / Commercial Appeal / Landov

Photographer Richard Copley in Memphis on March 18, 1968. In his first paid job as a photographer, Copley was sent to the Mason Temple, where the Rev. Martin Luther King, Jr. rallied a large crowd of sanitation workers. It was the same location where King would later deliver his famous "Mountaintop" speech.

NBC News

Photographer Richard Copley with the Rev. Cleophus Smith, who was a young man when he participated in the sanitation workers' strike in 1968.

By Christina Caron, NBC News

Richard Copley was just 22 when he got his first paid job as a photographer. But that assignment propelled him into one of the most significant historical events of the 20th century -- and his career.

?I had no idea what I was stepping into,? he told NBC News during his first media interview from his home in Fisherville, Tenn. ?I guess the biggest story of my life and ironically the first.?

As the photographer for the American Federation of State, County, and Municipal Employees (AFSCME) union, Copley was initially asked to attend the Rev. Martin Luther King Jr.?s March 18, 1968, speech in Memphis, Tenn., (pictured above) where the civil rights leader spoke to thousands of sanitation workers who were fighting for better pay and improved safety standards after two Memphis garbage collectors were crushed to death by their truck?s trash compactor.

Richard Copley

The most famous of Richard Copley's sanitation strike photos featured the iconic "I Am a Man" posters carried by striking members of Memphis Local 1733 during the march led by Dr. Martin Luther King Jr. on March 28, 1968.

King promised to come back and lead a protest across the city, and on March 28, he did. At the march Copley captured what is now his most famous image: the sea of signs reading, ?I Am a Man.? It didn?t take long, however, for things to turn violent.

?You could hear the glass breaking.? I knew all hell was breaking loose. I will have to say it was exhilarating and terrifying all at once,? said Copley, who got pepper-sprayed during the event.?

Richard Copley

The National Guard arrived in Memphis on March 29, 1968, after the sanitation workers' strike turned violent.

King was quickly pulled out of the protest as the violence escalated, and the next day the National Guard showed up.

?It was frightening ? it looked like a war zone. It was just a show of force, obviously, and ... in my mind it was overreaching. But on the other hand you have to consider the time ? it was 1968, and there had been riots in other cities, so I?m sure the 'powers that be' thought it was necessary,? Copley said.

During the peaceful march held on March 29, Copley shot the image that would become his favorite, the one he called ?Dignity?: a photo of two men holding poster boards in their best Sunday attire.

That combo of their formal dress and ?the stern looks on their faces? has always stood out in Copley?s mind, he said. ?

Richard Copley

Sanitation workers the Rev. Theodore Hibbler, left, and Ted Brown march in downtown Memphis on March 29, 1968, the day after the famous sanitation strike march led by Dr. Martin Luther King Jr. was shattered by violence.

King returned to Memphis on April 3 and was assassinated the following day from the balcony?of the Lorraine Motel.?

Richard Copley

The King family at the April 8, 1968, memorial march for the Rev. Martin Luther King Jr., which was attended by an estimated 42,000 people and led by his widow, Coretta Scott King.

Now, 45 years later, the 67-year-old photographer still has a camera in his hand. Now, though, instead of a 35mm, he shoots video in 1080i HD. As a freelance photographer, his work has appeared on several network news broadcasts, including "Nightly News with Brian Williams." ?

Although he has covered several major events such as 9/11 and Hurricane Katrina, Copley says his most memorable assignment was in Memphis in 1968.

??What these men did was incredible,? he said. ?They were courageous. This was 1968, ? and to do what they did makes them heroes.??

Richard Copley?s photography is currently being featured at the National Civil Rights Museum?in Memphis, Tenn. The exhibit will be moved to Memphis City Hall later this month.?

?

Richard Copley

During the April 8, 1968, memorial march to honor the Rev. Martin Luther King Jr., who had been shot four days earlier, Richard Copley captured this image of a white man holding an African-American child. Labor groups from all over the country showed up to pay tribute to the Memphis workers and King.

It's been 45 years since Martin Luther King Jr. was killed after coming to Memphis, Tenn., to support the sanitation workers' strike. Two of the men who demonstrated in the streets that day spoke with NBC's Ann Curry about their fight to make a better community for their families.

Source: http://feeds.nbcnews.com/c/35002/f/653381/s/2a5dbad0/l/0Lphotoblog0Bnbcnews0N0C0Inews0C20A130C0A40C0A40C1760A33540Ememphis0Eprotests0Ehow0Erookie0Ephotographer0Ecaptured0Ehistory0Dlite/story01.htm

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As singer Oday Khatib awaits Israeli military trial, testimonials pour in from around the world. (Update: trial postponed until April 8)

Oday Khatib, performing in France in 2012. Photo from France TV, DR / Culturebox

Testimonials from around the world are pouring in for Oday Khatib, the celebrated, star singer of Ramallah-based?Al Kamandjati music school, who faces Israeli military trial on Monday, April 8. ?(The trial was earlier scheduled for April 3.) As I?wrote recently, Oday was arrested March 19 for allegedly throwing stones at soldiers. ?As the 22-year old singer from Al Fawwar refugee camp awaits trial in?Ofer Prison near Ramallah, his friends, fellow musicians and supporters of Al Kamandjati, founded by Palestinian musician?Ramzi Aburedwan, are lighting up social media sites in support and musical witness.

?Oday and Ramzi came to London to perform with me and my group Fifth Quadrant last year,? writes Simon Hewitt-Jones, a British violinist who has taught numerous workshops at Al Kamandjati. ?His?intensely moving singing had a profound effect on audiences in London. ?We also took him to Aldeburgh to work with young British musicians, who were astounded that someone so young ? someone barely older than they were ? could have such an powerful musical voice, and such inspirational artistry.?

?Working with Al Kamandjati in Palestine, it was a joy to see Oday every day,? wrote Mariam Tamari, a Japanese-Palestinian opera singer based in Paris. Mariam, who sang Mozart?s peace plea, ?Alleluia Exultate Jubilate,? for the launching of the Palestinian National Orchestra in Jerusalem on New Years Eve, 2010, writes of Oday: ?He is truly a noble soul, communicating the warmth of his heart and quiet strength, and with a great capacity to appreciate beauty.?

?Oday is a true Palestinian voice who sears the receptive heart with his song, [which] is absolutely connected to his soul,? writes Peter Sulski, an American violist formerly of the London Symphony Orchestra, and who has taught for years at Al Kamandjati. ??He is a man of peace who would rot behind bars.?

Oday?s father, Jihad Khatib, told Musa Abuhashhash, a field worker for B?tselem, the Israeli human rights organization, that Oday was arrested at Al Fawwar while waiting for a friend he was meeting for dinner. Nearby, Jihad said, some youths were throwing stones, ?and when the soldiers chased the kids, it did not come to his mind that the soldiers would go for him. ?Otherwise he would have run away.?

Oday?s father, joined by musicians from the U.S., UK, Italy, France, Palestine, and elsewhere, expressed skepticism that Oday would have been throwing stones. He has never been arrested, and has long sought his resistance to occupation only through his singing, ?since he was nine years old,? Jihad said.

?He is a very lovely and peaceful boy only interested in one thing: singing,? wrote Sarah Roger, who came to Ramallah from France to volunteer the Al Kamandjati office. ?His only aim is to spread love and make people happy thanks to his beautiful voice.?

?His remarkable professionalism, his sweet voice and most of all his deep knowledge concerning teaching music and peace values to the kids, in order to create better human beings for the future, is outstanding and moving at the same time,? declared Luca Francetti and Gunilla Kerrich, husband and wife cellist and violinist, respectively, writing from Italy. ??His contribution to improve a better peace and brotherhood culture is essential. ?We really hope that all this talent won?t be wasted.?

Oday?s family has expressed hope that several of the soldiers who chased the youths on March 19 will be willing to testify that Oday was not among the stone-throwers. ?This does not appear likely: The?conviction rate for such alleged offenses in military trials, in 2010, was about 399 out of 400.

Beyond whether or not Oday was ?guilty? of throwing stones is the question of what constitutes legitimate Palestinian resistance to a 47-year military occupation. Al Fawwar, like most Palestinian villages and towns, sits on land surrounded by Israeli settlements. ?The camp is in the midst of Area C, under full Israeli military control, which takes up 60 percent of the West Bank. ?A central purpose of Israel?s occupation army is to protect the settlers, whose illegal occupation, under international law, remains a towering obstacle to a just settlement between Israel and the Palestinians. ?For generations of Palestinian youths, throwing stones has formed the core of their efforts at expelling the occupying army. ?Stone-throwing was at the heart of the first Palestinian ?intifada, which forced Israeli leaders to the negotiating table. ?(The Oslo agreement they forged with Palestinian negotiators proved to be disastrous; nevertheless, there was a palpable since during the first?intifada that the stone would lead to Palestinian liberation.)

I have spoken with several American officials in recent days regarding Oday?s arrest. ?The Americans have provided funds to Al Kamandjati to help support its past summer music camps, where Oday was featured prominently. ?Thus I thought they would take an interest in Oday?s case. ?My inquiry ? whether the American government would at least inquire about Oday?s incarceration ? was met with virtual silence. ?I just don?t have anything for you on that,? U.S. Embassy spokesman Geoff Anisman told me four or five times from Tel Aviv. ?Another American official in the region was only slightly more forthcoming: ??There?s a system in place,? the official said, referring to Israel?s system of arrest and incarceration.

Yes, there?s a system in place: ?A military court system in which 99.74 percent of the accused are convicted. ?The sentence for adults convicted of throwing stones ?[a]t a person or property, with the intent to harm the person or property shall be sentenced to ten years imprisonment,? according to Section 212 of Israeli Military Order 1651. ?Some of the convicted ?adults? are as young as 16; many of them plead guilty in exchange for a lesser sentence. ?A significant portion of the incarcerated are children ? 7000 in the last ten years, according to a UNICEF report, which states: ?the common experience of many children is being aggressively awakened in the middle of the night by many armed soldiers and being forcibly brought to an interrogation centre tied and blindfolded, sleep deprived and in a state of extreme fear. Few children are informed of their right to legal counsel.?

Adults like Oday know full well that they could receive a lengthy prison sentence. Currently more than 4,700 Palestinians are being held in Israeli prisons. ?Oday?s case is no more or less unfair than thousands of others; it simply sheds more light on the system that?s in place. ?And it prompts dozens of Oday?s friends and fellow musicians to write in his defense:

?Oday is an exemplary young man of noble, peaceful character,? writes Clemency Burton-Hill, a British violinist who has performed with the West Eastern Divan Orchestra, founded by the Israeli-Argentine conductor Daniel Barenboim and the late Palestinian intellectual Edward Said. ??Moreover he is the sort of young Palestinian that the Israelis should be supporting and celebrating, not imprisoning, for it is empathetic, inspiring people like Oday who might one day help to forge a lasting peace between Israel and the Palestinians.?If Oday spends the next ten years or even ten months, weeks or days in jail, that prospect of that peace will be further jeopardized. I am sickened to my heart at the prospect of what such a jail term might mean, both for Oday, his family, his friends and all who have been touched by his music.?

Nowras Ibrahim, an Al Kamandjati-trained Palestinian bass player who is now studying in France, writes that Oday ?has been more than a brother to me. We shared special moments together, discovering the world by spreading our music to people. ?Oday is known [for] his sensitivity. ?He sings from his heart.?

Julia Katarina, the British Mezzo-Soprano who put her opera career on hold to teach voice lessons at Al Kamandjati for three years, writes of Oday: ??He?is?very generous with his art, and just loves?singing beyond all else!?He is a true singer, and I?imagine?the only way he is surviving prison is by singing.?I hope he sings in the military court,? Julia writes, because on April 8, if Oday?s accusers can find ?an ounce of humanity in their hearts, they will release him.?

Note: ?This article will be updated with additional testimonials.

Source: http://ramallahcafe.com/?p=706

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Official: Obama proposes cuts to Social Security

WASHINGTON (AP) ? President Barack Obama is proposing cuts to Social Security as an attempt to compromise with Republicans on the budget.

A senior administration official says the budget Obama will offer to Congress next Wednesday would reduce the deficit by $1.8 trillion over 10 years. It includes a revised inflation adjustment called "chained CPI" that would curb cost-of-living increases in Social Security and other benefit programs.

The senior administration official stressed it is not the president's preferred approach but a compromise proposal to try to reach a long-term budget deal. Obama first made the offer to House Speaker John Boehner last year.

The official spoke on a condition of anonymity since the budget has yet to be released. Technically, the administration actually would be limiting the growth of Social Security.

Source: http://news.yahoo.com/official-obama-proposes-cuts-social-security-111357788--finance.html

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Official: Obama proposes cuts to Social Security

President Barack Obama speaks at the Denver Police Academy in Denver, Wednesday, April 3, 2013. Ratcheting up pressure for Congress to limit access to guns, Obama said that steps taken recently by Colorado to tighten its gun laws show "there doesn't have to be a conflict" between keeping citizens safe and protecting Second Amendment rights to gun ownership. (AP Photo/Susan Walsh)

President Barack Obama speaks at the Denver Police Academy in Denver, Wednesday, April 3, 2013. Ratcheting up pressure for Congress to limit access to guns, Obama said that steps taken recently by Colorado to tighten its gun laws show "there doesn't have to be a conflict" between keeping citizens safe and protecting Second Amendment rights to gun ownership. (AP Photo/Susan Walsh)

(AP) ? President Barack Obama's proposed budget will call for reductions in the growth of Social Security and other benefit programs while still insisting on more taxes from the wealthy in a renewed attempt to strike a broad deficit-cutting deal with Republicans, a senior administration official says.

The proposal aims for a compromise on the Fiscal 2014 budget by combining the president's demand for higher taxes with GOP insistence on reductions in entitlement programs.

The official, who spoke on a condition of anonymity to describe a budget that has yet to be released, said Obama would reduce the federal government deficit by $1.8 trillion over 10 years. The president's budget, the first of his second term, incorporates elements from his last offer to House Speaker John Boehner in December. Congressional Republicans rejected that proposal because of its demand for more than a $1 trillion in tax revenue.

A key feature of the plan Obama now is submitting for the federal budget year beginning Oct. 1 is a revised inflation adjustment called "chained CPI." This new formula would effectively curb annual increases in a broad swath of government programs, but would have its biggest impact on Social Security. By encompassing Obama's offer to Boehner, R-Ohio, the plan will also include reductions in Medicare spending, much of it by targeting payments to health care providers and drug companies.

Obama's budget proposal also calls for additional tax revenue, including a proposal to place limits on tax-preferred retirement accounts for wealthy taxpayers. Obama has also called for limits on tax deductions by the wealthy, a proposal that could generate about $580 billion in revenue over 10 years.

The inflation adjustment would reduce federal spending over 10 years by about $130 billion, according to past White House estimates. Because it also affects how tax brackets are adjusted, it would also generate about $100 billion in higher taxes and affect even middle income taxpayers.

The reductions in the growth of benefit programs, which would affect veterans, the poor and the older Americans, is sure to anger many Democrats. Labor groups and liberals have long been critical of Obama's offer to Boehner for including such a plan.

Administration officials have said Obama would only agree to the reductions in benefit programs if they are accompanied by increases in revenue, a difficult demand given the strong anti-tax sentiment of House Republicans.

That Obama would include such a plan in his budget is hardly surprising. White House aides have said for weeks that the president's offer to Boehner in December remained on the table. Not including it in the budget would have constituted a remarkable retreat from his bargaining position.

Obama's budget, to be released next Wednesday, comes after the Republican-controlled House and the Democratic-run Senate passed separate and markedly different budget proposals. House Republicans achieved long-term deficit reductions by targeting safety net programs; Democrats instead protected those programs and called for $1 trillion in tax increases.

But Obama has been making a concerted effort to win Republican support, especially in the Senate. He has even scheduled a dinner with Republican lawmakers on the evening that his budget is released next week.

House Republicans, however, have been adamant in their opposition to increases in taxes, noting that Congress already increased taxes on the wealthy in the first days of January to avoid a so-called fiscal cliff, or automatic, across the board tax increases and spending cuts.

Congress and the administration have already secured $2.5 trillion in deficit reduction over the next 10 years through budget reductions and with the end-of-year tax increase on the rich. Obama's plan would bring that total to $4.3 trillion over 10 years.

As described by the administration official, the budget proposal would also end a loophole that permits people to obtain unemployment insurance and disability benefits at the same time.

Obama's proposal, however, includes calls for increased spending. It would make pre-school available to more children by increasing the tax on tobacco.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/89ae8247abe8493fae24405546e9a1aa/Article_2013-04-05-Obama-Budget/id-5b430118986f4c5d925bb0d780e67131

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A 'light switch' in brain illuminates neural networks: Scientists can see cells communicate by flipping a neural light switch

Apr. 4, 2013 ? There are cells in your brain that recognize very specific places, and have that as one of their main jobs. These cells, called place cells, are found in an area behind your temple called the hippocampus. While these cells must be sent information from nearby cells to do their job, so far no one has been able to determine exactly what kind of nerve cells, or neurons, work with place cells to craft the code they create for each location. Neurons come in many different types with specialized functions. Some respond to edges and borders, others to specific locations, others act like a compass and react to which way you turn your head.

Now, researchers at the Kavli Institute for Systems Neuroscience at the Norwegian University of Science and Technology have combined a range of advanced techniques that enable them to identify which neurons communicate with each other at different times in the rat brain, and in doing so, create the animal's sense of location. Their findings are published in the 5 April issue of Science.

"A rat's brain is the size of a grape. Inside there are about fifty million neurons that are connected together at a staggering 450 billion places (roughly)," explains Professor Edvard Moser, director of the Kavli Institute. "Inside this grape-sized brain are areas on each side that are smaller than a grape seed, where we know that memory and the sense of location reside. This is also where we find the neurons that respond to specific places, the place cells. But from which cells do these place cells get information?"

The problem is, of course, that researchers cannot simply cut open the rat brain to see which cells have had contact. That would be the equivalent of taking a giant pile of cooked spaghetti, chopping it into little pieces, and then trying to figure out how the various spaghetti strands were tangled together before the pile was cut up.

A job like this requires the use of a completely different set of neural tools, which is where the "light switches" come into play.

Neurons share many similarities with electric cables when they send signals to each other. They send an electric current in one direction -- from the "body" of the neuron and down a long arm, called the axon, which goes to other nerve cells. Place cells thus get their small electric signals from a whole series of such arms.

So how do light switches play into all of this?

"What we did first was to give these nerve arms a harmless viral infection," Moser says. "We designed a unique virus that does not cause disease, but that acts as a pathway for delivering genes to specific cells. The virus creeps into the neurons, crawls up to the nucleus of the cell, and uses the nerve cell's own factory to make the genetic recipe that we gave to the virus to carry."

The genetic recipe enabled the cell to make the equivalent of a light switch. Our eyes actually contain the same kind of biological light switch, which allows us to see. The virus infection converts neurons that have previously existed only in darkness, deep inside the brain, to now be sensitive to light.

Then the researchers inserted optical fibres in the rat's brain to transmit light to the different unidentified cells that now had light switches in them. They also implanted thin microelectrodes down between the cells so they could detect the signals sent through the axons every time the light from the optical fibre was turned on.

"Now we had everything set up, with light switches installed in cells around the place cells, a lamp, and a way to record the activity," Moser said.

The researchers then turned the lights on and off more than ten thousand times in their rat lab partners, while they monitored and recorded the activity of hundreds of individual cells in the rats' grape-sized brains. The researchers did this research while the rats ran around in a metre-square box, gathering treats. As the rats explored their box and found the treats, the researchers were able to use the light-sensitive cells to figure out which cells were feeding information to the place cells as the rat's brain created the map of where the rat had been.

When the researchers put together all the information afterwards they concluded that there is a whole range of different specialized cells that together provide place cells their information. The brain's GPS -- its sense of place -- is created by signals from head direction cells, border cells, cells that have no known function in creating location points, and grid cells. Place cells thus receive both information about the rat's surroundings and landmarks, but also continuously update their own movement, which is actually independent on sensory input.

"One mystery is the role that the cells that are not part of the sense of direction play. They send signals to place cells, but what do they actually do?" wonders Moser.

"We also wonder how the cells in the hippocampus are able to sort out the various signals they receive. Do they 'listen' to all of the cells equally effectively all the time, or are there some cells that get more time than others to 'talk' to place cells?"

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The above story is reprinted from materials provided by Norwegian University of Science and Technology, via EurekAlert!, a service of AAAS.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. Sheng-Jia Zhang*,?, Jing Ye*, Chenglin Miao, Albert Tsao, Ignas Cerniauskas, Debora Ledergerber, May-Britt Moser, Edvard I. Moser. Optogenetic Dissection of Entorhinal-Hippocampal Functional Connectivity. Science, 5 April 2013: Vol. 340 no. 6128 DOI: 10.1126/science.1232627

Note: If no author is given, the source is cited instead.

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10 million pounds of frozen pizza, snacks recalled in rare E. coli outbreak

By JoNel Aleccia, Senior Writer, NBC News

A New York snack food maker now says it is recalling 10 million pounds of frozen pizza, mozzarella bites, Philly cheese steaks and other products linked to a rare and potentially dangerous outbreak of E. coli poisoning. Three million pound of the products remain in the marketplace, a company spokesman said Friday.

Rich Products Corp. of Buffalo, N.Y., is pulling all products manufactured at its Waycross, Ga., plant. The ?snacks have best buy dates from Jan. 1 2013 through Sept. 29, 2014, according to a press release.?For a full list of products, click here.

The company spokesman originally said three million pounds of the products were recalled, but later confirmed that the company also had control of seven million pounds of the frozen items that had not reached stores.

The foods may be contaminated with the bacterium E. coli O121, which already has sickened 24 people in 15 states who ate certain Farm Rich and Market Day frozen chicken quesadillas, pizza slices and other snack foods. Seven people have been hospitalized, according to the Centers for Disease Control and Prevention.

However, many more people may have been made ill by the products without knowing it because of complexities involved in identifying? E. coli O121, a strain that can be just as dangerous as the better-known E. coli O157:H7 frequently tied to outbreaks caused by hamburger.

The Thursday announcement expands a March 28 recall?of 196,222 pounds of Farm Rich brand frozen chicken quesadillas and other frozen mini meals and snack items because they could be contaminated with E. coli O121.

The strain is among a potentially lethal group of bacteria known as Shiga-toxin producing E. coli or STECs. The bacteria, which include E. coli O157, create poisons that can lead to severe illness and disease, including bloody diarrhea, kidney failure and death.

In 2011, U.S. Department of Agriculture officials banned E. coli O121 and five other strains -- known as ?the big six? -- from the nation?s beef supply. This outbreak is the first time Food Safety and Inspection Service officials have recalled products potentially tainted with E. coli O121.

The bacteria are tough to identify in outbreaks because clinical laboratories typically test only for the E. coli O157 strains. To detect the other strains, labs must screen for the presence of Shiga toxins and then send positive samples to public health laboratories to find any non-E. coli O157 STECs.

The strain involved in this outbreak is so rare, its genetic fingerprint has been seen less than 30 times in PulseNet, the CDC?s network of laboratories that track bacteria involved in foodborne illness.

The New York state Department of Health identified the outbreak strain of E. coli O121 in an opened package of Farm Rich brand frozen mini chicken and cheese quesadillas from an ill person?s home, the CDC said.

People usually become sick from Shiga-toxin producing E. coli within two to eight days after eating contaminated food. ?Symptoms include bloody diarrhea and abdominal cramps. Most people recover within a week, but others can become severely ill with a complication called hemolytic uremic syndrome, or HUS, which causes kidney failure.

Children and the elderly are most vulnerable to the worst effects of the illness.

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